Professor WU Yaojiong
Post Time :2010-12-20 14:41:17

Contact Information

Tel 0086 (0)755 26036348

Email wu.yaojiong@sz.tsinghua.edu.cn

Education

1978-1983 M.D., Qingdao Medical College

1983-1986 M.S., Lanzhou University

2000-2003 Ph.D., University of Toronto

Employment

2008-present, Professor, Life Science Division, Graduate School at Shenzhen, Tsinghua

University, China

2005-2008, Assistant Professor, Department of Surgery; Department of

Biochemistry, Faculty of Medicine and Dentistry, University of Alberta,

Canada

2003-2005, Research Associate, Department of Medicine, Brigham & Women’s

Hospital and Harvard Medical School, Boston; and Duke University

Medical Center, Durham (Lab relocation), USA.

1998-1999, Postdoctoral Fellow, University of British Columbia, Vancouver, Canada

1986-1997, Physician, Cardiologist, Department of Medicine, Xuanwu Hospital,

Capital University of Medical Science, Beijing, China

1994-1997, Associate Professor, Department of Medicine, Xuanwu Hospital, Capital University of Medical Science, Beijing, China

Research Fields

•molecular mechanisms of mesenchymal stem cell-mediated tissue repair/regeneration;

•ECM molecules in enhancing mesenchymal stem cell survival and engraftment after transplantation;

•epigenetic regulation of mesenchymal stem cell aging and differentiation;

•mesenchymal stem cells in tissue engineering.

Selected publications:

•Wu Y, Zhao RC, and Tredget EE. (2010) Bone marrow derived stem/progenitor cells in cutaneous repair and regeneration. Stem Cells. accepted.

•Chen L, Tredget E, Liu CX, and Wu Y*. (2009) Analysis of allogenicity of mesenchymal stem cells in engraftment and wound healing. PLoS ONE 22;4:e7119.

•Wu Y*, and Wu PY. (2009) CD133 as a marker for cancer stem cells: progresses and concerns. Stem Cells and Development. 18:1127-34.

•Chen L., Tredget E., Wu P., and Wu Y*. (2008). Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS ONE. 2;3:e1886

•Wu Y*, Chen W, Scott P, and Tredget EE. (2007) Bone marrow derive mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells25: 2648-2659.

•Wu Y*, Ip JE*, Zhang LN, Lopez-Ilasaca MA, Pratt RE and Dzau VJ. (2007) Molecular mechanisms of mesenchymal stem cell homing and engraftment into the injured tissues. Mol. Biol. Cell. 18:2873-82 (*equal contribution).

•Wu Y, Wang J and Tredget EE. (2007) Bone marrow derived stem cells in wound healing: A Review. Wound Repair Regen 15 (s1): S18–S26.

•Matsushita K, Wu Y, Okamoto Y, Pratt RE, and Dzau VJ. (2006) Local renin angiotensin expression regulates human mesenchymal stem cell differentiation to adipocytes. Hypertension 48:1095-102.

•Wu Y, Ip JE, Huang J, Zhang LN, Matsushita K, Liew CC, Pratt RE, and Dzau VJ. (2006) Essential Role of ICAM-1/CD18 in Mediating EPC Recruitment, Angiogenesis and Repair to the Infarcted Myocardium. Circ Res. 99: 315-322.

•Wu Y, Wu J, Cao L, Chen L, Zhang Y, Kiani C, and Yang BB. (2005) Versican protects cells from oxidative stress-induced apoptosis. Matrix Biol. 24:3-13.

•Wu Y, La Pierre DP, Wu J, Yee AJ, and Yang BB. (2005) The interaction of versican with its binding partners. Cell Res. 15: 483-94.

•Wu Y, Chen L, Cao L, Sheng W, and Yang BB. (2004) Expression of the C-terminal PG-M/versican domain reverses cell transformation and tumorigenesis by modulating the interaction of epidermal growth factor receptor and β1-integrin. J. Cell Science 117:2227-2237.

•Wu Y, Sheng W, Chen L, Dong H, Lee V, Lu F, Wong CS, Lu, WY, and Yang BB. (2004) Versican V1 isoform induces neuronal differentiation and neurite outgrowth. Mol. Biol. Cell 15:2093-104.

•WuY, Chen L, Zheng PS, and Yang BB. (2002) 1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PG-M/Versican. J. Biol. Chem. 277: 12294-12301.

•Wu Y, Zhang Y, Cao L, Chen L, Lee V, Zheng PS, Kiani C, Adams ME, Ang LC, Paiwand F and Yang BB. (2001)Identification of the motif in versican G3 domain that plays a dominant-negative effect on astrocytoma cell proliferation through inhibiting versican secretion and binding. J. Biol. Chem. 276: 14178-14186.