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曾小伟 讲师 主要从事生物医用材料、药物递送和纳米医学等领域研究

 姓名:曾小伟

职称:讲师

所属学科:生物学

 

【联系方式】

电话:0755-26035209

传真:0755-26035209

E-mailzeng.xiaowei@sz.tsinghua.edu.cn   or   xwzeng@163.com

 

【个人简历】

教育经历:

2006.09~2011.06,南开大学,化学学院高分子化学与物理专业,博士

2002.09~2006.06,江西师范大学,化学化工学院应用化学专业,学士

工作经历:

2014.03~至今,清华大学,深圳研究生院,讲师

2012.03~2014.03,清华大学,深圳研究生院,生物学博士后

2011.07~2012.02,东北大学,资源与材料学院,讲师

 

【研究领域】

主要从事生物医用材料、药物递送系统和吸附分离材料等领域的研究。在Advanced MaterialsAdvanced Functional MaterialsBiomaterialsActa BiomaterialiaTheranosticsAdvanced Healthcare Materials等国际知名期刊发表SCI收录论文40余篇,被引用次数累积700余次,申请国家发明专利10项。先后承担国家自然科学基金、广东省自然科学基金、深圳市战略性新兴产业发展专项资金和中国博士后科学基金等国家和省部级项目7项,以主要成员身份参与国家自然科学基金面上项目3项。获得深圳市自然科学二等奖。

 

【代表性论文与专利】

[1] Xiaowei Zeng, Gan Liu, Wei Tao, Yue Ma, Xudong Zhang, Fan He, Jianming Pan*, Lin Mei*, Guoqing Pan*, A drug-self-gated mesoporous antitumor nanoplatform based on pH-sensitive dynamic covalent bond, Advanced Functional Materials 2017 DOI: 10.1002/adfm.201605985  (Cover Paper)

[2] Wei Tao, Xianbing Zhu, Xinghua Yu, Xiaowei Zeng, Quanlan Xiao, Xudong Zhang, Xiaoyuan Ji, Xusheng Wang, Jinjun Shi*, Han Zhang*, Lin Mei*, Black phosphorus nanosheets as a robust delivery platform for cancer theranostics, Advanced Materials 29 (2017) 1603276.  (Cover Paper)

[3] Gan Liu1, Hsiang-i Tsai1, Xiaowei Zeng1 (Co-first authors), Yixiong Zuo, Wei Tao, Jun Han, Lin Mei*, Phosphorylcholine-based stealthy nanocapsules enabling tumor microenvironment-responsive doxorubicin release for tumor suppression, Theranostics 7 (2017) 1192-1203.

[4] Gan Liu, Hongjun Gao, Yixiong Zuo, Xiaowei Zeng, Wei Tao, Hsiang-i Tsai, Lin Mei*DACHPt-loaded unimolecular micelles based on hydrophilic dendritic block copolymers for enhanced therapy of lung cancer, ACS Applied Materials & Interfaces 9 (2017) 112-119.

[5] Dunwan Zhu, Wei Tao, Hongling Zhang, Gan Liu, Teng Wang, Linhua Zhang, Xiaowei Zeng*, Lin Mei*, Docetaxel (DTX)-loaded polydopamine-modified TPGS-PLA nanoparticles as a targeted drug delivery system for the treatment of liver cancer, Acta Biomaterialia 30 (2016) 144-154.

[6] Danfeng Chang, Yongfeng Gao, Lijun Wang, Gan Liu, Yuhan Chen, Teng Wang, Wei Tao, Lin Mei, Laiqiang Huang*, Xiaowei Zeng*, Polydopamine-based surface modification of mesoporous silica nanoparticles as pH-sensitive drug delivery vehicles for cancer therapy, Journal of Colloid and Interface Science 463 (2016) 279-287.

[7] Wei Tao1, Xiaowei Zeng1 (Co-first authors), Jun Wu, Xi Zhu, Xinghua Yu, Xudong Zhang, Jinxie Zhang, Gan Liu, Lin Mei*, Polydopamine-based surface modification of novel nanoparticle-aptamer bioconjugates for in vivo breast cancer targeting and enhanced therapeutic effects, Theranostics 6 (2016) 470-484.  (Cover Paper)

[8] Xiaowei Zeng, Wei Tao, Zhongyuan Wang, Xudong Zhang, Huijun Zhu, Yanping Wu, Yongfeng Gao, Kewei Liu, Yuyang Jiang, Laiqiang Huang, Lin Mei*, Si-Shen Feng*, Docetaxel-loaded nanoparticles of dendritic amphiphilic block copolymer H40-PLA-b -TPGS for cancer treatment, Particle & Particle Systems Characterization 32 (2015) 112-122.

[9] Wei Tao, Jinxie Zhang, Xiaowei Zeng*, Danny Liu, Gan Liu, Xi Zhu, Yanlan Liu, Qingtong Yu, Laiqiang Huang*, Lin Mei*, Blended nanoparticle system based on miscible structurally similar polymers: a safe, simple, targeted, and surprisingly high efficiency vehicle for cancer therapy, Advanced Healthcare Materials 4 (2015) 1203-1214.   (Back Cover Paper)

[10] Teng Wang, Dunwan Zhu, Gan Liu, Wei Tao, Wei Cao, Linhua Zhang, Lijun Wang, Hongbo Chen, Lin Mei, Laiqiang Huang*, Xiaowei Zeng*, DTX-loaded star-shaped TAPP-PLA-b-TPGS nanoparticles for cancer chemical and photodynamic combination therapy, RSC Advances 5 (2015) 50617-50627.  

[11] Xiaowei Zeng*, Wei Tao, Lin Mei, Si-Shen Feng*, Docetaxel-loaded nanoparticles of dendrimer-like amphiphilic copolymer for cancer therapy, Journal of Controlled Release 213 (2015) E119-E119.

[12] Nansha Gao, Zhihong Chen, Xiaojun Xiao, Changshun Ruan, Lin Mei, Zhigang Liu*, Xiaowei Zeng*, Surface modification of paclitaxel-loaded tri-block copolymer PLGA-b-PEG-b-PLGA nanoparticles with protamine for liver cancer therapy, Journal of Nanoparticle Research 17 (2015) 347.

[13] Xudong Zhang1, Xiaowei Zeng1 (Co-first authors), Xin Liang, Ying Yang, Xiaoming Li, Hongbo Chen, Laiqiang Huang, Lin Mei*, Si-Shen Feng*, The chemotherapeutic potential of PEG-b-PLGA copolymer micelles that combine chloroquine as autophagy inhibitor and docetaxel as an anti-cancer drug, Biomaterials 35 (2014) 9144-9154.

[14] Xudong Zhang, Yichen Dong, Xiaowei Zeng, Xin Liang , Xiaoming Li, Wei Tao, Hongbo Chen, Yuyang Jiang, Lin Mei*, Si-Shen Feng*, The effect of autophagy inhibitors on drug delivery using biodegradable polymer nanoparticles in cancer treatment, Biomaterials 35 (2014) 1932-1943.

[15] Huijun Zhu1, Hongbo Chen1, Xiaowei Zeng1 (Co-first authors), Zhongyuan Wang, Xudong Zhang, Yanping Wu, Yongfeng Gao, Jinxie Zhang, Kewei Liu, Ranyi Liu, Lintao Cai, Lin Mei*, Si-Shen Feng*, Co-delivery of chemotherapeutic drugs with vitamin E TPGS by porous PLGA nanoparticles for enhanced chemotherapy against multi-drug resistance, Biomaterials 35 (2014) 2391-2400.

[16] Xudong Zhang, Ying Yang, Xin Liang, Xiaowei Zeng, Zhigang Liu, Wei Tao, Xiaojun Xiao, Hongbo Chen, Laiqiang Huang*, Lin Mei*, Enhancing therapeutic effects of docetaxel-loaded dendritic copolymer nanoparticles by co-treatment with autophagy inhibitor on breast cancer, Theranostics 4(2014) 1085-1095.

[17] Xiaowei Zeng, Wei Tao, Lin Mei*, Laiqiang Huang, Chunyan Tan, Si-Shen Feng*, Cholic acid-functionalized nanoparticles of star-shaped PLGA-Vitamin E TPGS copolymer for docetaxel delivery to cervical cancer. Biomaterials 34 (2013) 6058-6067.

[18] Ruihui Liu, Nansha Gao, Feng Zhen, Yuyan Zhang, Lin Mei*, Xiaowei Zeng*, Doping effect of Al2O3 and CeO2 on Fe2O3 support for gold catalyst in CO oxidation at low-temperature. Chemical Engineering Journal 225 (2013) 245-253

[19] Wei Tao1, Xiaowei Zeng1 (Co-first authors), Ting Liu, Zhongyuan Wang, Qingqing Xiong, Chunping Ouyang, Laiqiang Huang*, Lin Mei*, Docetaxel-loaded nanoparticles based on star-shaped mannitol-core PLGA-TPGS diblock copolymer for breast cancer therapy, Acta Biomaterialia 9 (2013) 8910-8920.

[20] Xiaojun Xiao1, Xiaowei Zeng1 (Co-first authors), Xinxin Zhang, Li Ma, Xiaoyu Liu, Haiqiong Yu, Lin Mei*, Zhigang Liu*, Effects of Caryota mitis profilin-loaded PLGA nanoparticles in a murine model of allergic asthma, International Journal of Nanomedicine 8 (2013) 4553-4562.

[21] Xiaowei Zeng, Hongbo Chen, Yi Zheng, Wei Tao, Yunge Fan, Laiqiang Huang*, Lin Mei*, Enhanced adsorption of puerarin onto a novel hydrophilic and polar modified post-crosslinked resin from aqueous solution, Journal of Colloid and Interface Science 385 (2012) 166-173.

[22] Xiaowei Zeng, Hongjie Yao, Ning Ma, Yunge Fan*, Chunhong Wang, Rongfu Shi, Synthesis, characterization and adsorption performance of a novel post-crosslinked adsorbent, Journal of Colloid and Interface Science 354 (2011) 353-358.

[23] Xiaowei Zeng, Tingjun Yu, Peng Wang, Ronghua Yuan, Qing Wen, Yunge Fan*, Chunhong Wang, Rongfu Shi, Preparation and characterization of polar polymeric adsorbents with high surface area for the removal of phenol from water, Journal of Hazardous Materials 177 (2010) 773-780.

[24] Xiaowei Zeng, Yunge Fan*, Guolin Wu, Chunhong Wang, Rongfu Shi, Enhanced adsorption of phenol from water by a novel polar post-crosslinked polymeric adsorbent, Journal of Hazardous Materials 169 (2009) 1022-1028.

[25] 曾小伟,梅林,黄来强,陶伟,郑义,陈红波,CA-(PLA-ran-PCL)-b-PEG嵌段共聚物及其制备方法与应用,公开号:CN103073730A   已授权,专利号:ZL 201210578931.0

[26] 梅林,曾小伟,黄来强,郑义,陈红波,一种CA-PLGA-TPGS星型共聚物及其制备方法与应用,公开号:CN102807677 A   已授权,专利号:ZL 201210292220.7

 

【兼职情况】

深圳市科技专家库评审专家

深圳市高技术产业化项目评审专家

中国生物材料学会会员

中国化学会会员

BiomaterialsNanomedicineActa BiomaterialiaInternational Journal of NanomedicineJournal of NanobiotechnologyJournal of Colloid and Interface ScienceJournal of Nanoparticle Research等期刊的受邀审稿人。

 

【奖励荣誉】

2015年荣获深圳市自然科学二等奖

 

版权所有@清华大学深圳研究生院 地址:深圳大学城清华园区 邮编:518055 Email:info@sz.tsinghua.edu.cn