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李应福 兼职教授 鹏城学者 主要从事核酸结构和功能研究

 

 

姓名:李应福

职称:兼职教授,鹏城学者 博士生导师

 

【联系方式】

电话:(905) 525-9140 传真:(905) 522-9033

Email:liying@McMaster.CA

 

【个人简历】

2010- 麦克马斯特大学,教授(终身)

2005-2010 麦克马斯特大学,副教授

1999-2005 麦克马斯特大学,助理教授

1997-1999 耶鲁大学分子,细胞核发育生物学系,博士后

1992-1997 西蒙弗雷泽大学分子生物学和生物化学研究所化学和生物化学系,博士

1989-1992 安徽大学,讲师

1986-1989 中国农业大学应用化学系,硕士

1983-1986 安徽农业大学基础科学系,教师

1979-1983 安徽大学化学系,学士

 

【研究领域】

主要从事核酸结构和功能研究,体外进化,催化DNA,催化RNA,DNA和RNA适配体,核酸开关,非编码RNA,细菌毒素,酶学,核酸工程,分子诊断,生物传感,有机合成,高通量筛选,纳米粒子,DNA纳米技术和光谱等。

 

【主要荣誉】

2007-2009年获海外年轻中国学者研究卓越奖;

2006-2010年获加拿大首席科学家;

2004-2009年获安大略总理研究卓越奖;

2001-2005年获加拿大首席科学家;

1997-2000年获MRC博士后奖学金;

1998年获NSERC博士生奖;

1998年获加拿大总督学术金牌;

1997年获西蒙弗雷泽大学校长研究津贴;

1994-1997年获西蒙弗雷泽大学MacMillan-Bloedel奖学金;

1994-1996年获西蒙弗雷泽大学研究生奖学金;

1991年获中国农药工业协会安徽大学优秀工作者奖;

1989年获研究生研究成就奖

 

【研究成果】

1. Hossain, S. M. Z., Ozimok, C., Sicard, C., Aguirre, S. D., Ali, M. M., Li, Y. & Brennan, J. D. (2012). Multiplexed paper test strip for quantitative bacterial detection. Americal and Bioanalytical Chemistry. 403, 1567-1576.

2. Wang, G. N., Lau, P. S., Li, Y. & Ye, X. S. (2012). Synthesis and evaluation of glucosamine-6-phosphate analogues as activators of glmS riboswitch. 46, 9405-9412.

3. Carrasquilla, C., Lau, P. S., Li, Y. & Brennan, J. D. (2012). Stabilizing Structure-Switching Signaling RNA Aptamers by Entrapment in Sol-Gel Derived Materials for Solid-Phase Assays. Journal of American Chemical Society. 134, 10998-11005.

4. Lam, J. C. F., Kwan, S. O., & Li, Y. (2011). Characterization of Non-8-17 Sequences Uncovers Structurally Diverse RNA-cleaving Deoxyribozymes. Molecular BioSystems. 7, 2139-2146.

5. Xu, Y., Pharand, L., Wen, Q., Gonzaga, F., Ali, M. M., Li, Y., Filipe, C. D. M. & Pelton, R. (2011). Controlling Biotinylation of Microgels and Modeling Streptavidin Uptake. Colloid and Polymer Science. 289, 659-666.

6. Ali, M. M., Aguirre, S. D., Lazim, H. & Li, Y. (2011). Fluorogenic DNAzyme Probes as Bacterial Indicators. Angewandte Chemie International Edition. 50, 3751-4.

7. Carrasquilla, C., Li, Y. & Brennan, J. D. (2011). Surface Immobilization of Structure-Switching DNA Aptamers on Macroporous Sol-Gel-Derived Films for Solid-Phase Biosensing Applications. Analytical Chemistry. 83, 957-965.

8. Ali, M. M, Kanda, P., Aguirre, S. D. & Li, Y. (2011). Modulation of DNA-Modified Gold-Nanoparticle Stability in Salt with Concatemeric Single-Stranded DNAs for Colorimetric Bioassay Development. Chemistry – An European Journal. 17, 2052-2056.

9. Lau, P. & Li, Y. (2011). Functional nucleic acids for the recognition of small molecules. Curr. Org. Chem. 15, 557-575. Invited review.

10. Mok, W. W. K., Patel, N. & Li, Y. (2010). Decoding Toxicity: Deducing the Sequence Requirements of a Type I Toxin in Escherichia coli. Journal of Biological Chemistry. 285:41627-36.

11. Lau, P. L., Coombes, B. K. & Li, Y. (2010). A General Approach to the Construction of Structure-Switching Reporters from RNA Aptamers. Angew. Chem. Int. Ed. 49, 7938-7942.

12. McManus, S. A. & Li, Y. (2010). The Structural Diversity of Deoxyribozymes. Molecules. 15, 6269-6284. Review.

13. Wang, B., Cao, L., Chiuman, W., Li, Y. & Xi, Z. (2010). Probing the function of nucleotides in the catalytic cores of the 8-17 and 10-23 DNAzymes by abasic nucleotide and C3 spacer substitutions. Biochemistry 49, 7553-7562.

14. Lam, J. & Li, Y. (2010). Influence of Cleavage Site on Global Folding of an RNA-Cleaving DNAzyme. ChemBioChem. 11, 1710 – 1719.

15. Fowler, C. C., Brown, E. D. & Li, Y. (2010). Using a riboswitch sensor to monitor coenzyme B12 metabolism and transport in E. coli. Chem. Biol. 17, 756-765.

16. Lam, J. C., Withers, J. B. & Li, Y. (2010). A complex RNA-cleaving DNAzyme that can efficiently cleave a pyrimidine-pyrimidine junction. J. Mol. Biol. 400, 689-701.

17. Budz, H. A., Ali, M. M., Li, Y. & LaPierre, R. R. (2010). Photoluminescence Model for a Hybrid Aptamer-GaAs Optical Biosensor. J. Appl. Phys. 107, 104702 1-9.

18. Schlosser, K. & Li, Y. (2010). A versatile endoribonuclease made of DNA: characteristics and applications of the 8-17 DNAzyme. ChemBioChem. 11, 866-879. Review.

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