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刘峰 讲师 主要从事化学生物学研究

姓名:刘峰

职称:讲师

所属学科:化学生物学

【联系方式】

电话:0755-26036533

E-mail:liu.feng@sz.tsinghua.edu.cn

办公地址:深圳市南山区西丽大学城清华园区J栋402B

【个人简历】

1997年9月-2001年6月    河南工业大学微生物发酵工程专业本科毕业

2001年9月-2004年6月    河南工业大学农产品加工与贮藏工程专业硕士毕业

2004年9月-2008年7月    清华大学生物学专业博士毕业

2008年10月-2010年12月  清华大学深圳研究生院博士后

2011年1月至今          清华大学深圳研究生院生命与健康学部讲师

【教学】

《现代生命科学与生物技术实验》、《药物化学专题实验》

研究领域】

主要研究方向为肿瘤化学生物学,涉及肿瘤相关核酸分子探针研究、肿瘤细胞发生生长机理、细胞凋亡信号转导途径及抑制肿瘤细胞生长的抗癌药物研究等。首次建立了一种具有RNA剪切功能的适配体酶分子筛选系统,并利用此系统筛选出了对乳腺癌具有特异响应的分子探针,临床样品检测表明此探针对乳腺癌的筛查识别率达到了90%以上。建立了基于适配体的多种金属纳米粒子的分子探针体系,用于肿瘤相关生物分子的检测分析。首次在肝癌和乳腺癌中获得了以pokemon为中心的肿瘤信号传导网络,发现了一系列有效的抗肿瘤药物作用靶点和靶点组合,并提出了根据这些靶点进行抗肿瘤先导化合物的设计研发的方案。目前主要从事抗肿瘤药物先导化合物作用机制研究,肿瘤细胞生物标记物及肿瘤相关分子的识别检测等方面研究。主持承担了国家自然科学基金、深圳市基础研究等项目,作为项目主要研究骨干参与科技重大专项重大新药创制、科技部973计划、国际合作项目、科技部863项目、深圳市科技计划项目等科研项目多项。

【研究成果】

[1]     Wenlu Li, Qinsheng Sun, Lu Song, Chunmei Gao , Feng Liu*,Yuzong Chen, Yuyang Jiang*. Discovery of 1-(3-aryl-4-chlorophenyl)-3-(p-aryl)urea derivatives against breast cancer by inhibiting PI3K/Akt/mTOR and Hedgehog signalings, European Journal of Medicinal Chemistry, 2017,141,721-733

[2]     Tingting Fan, Yu Mao, Feng Liu, Wei Zhang, Jingxian Yin, Yuyang Jiang. Dual signal amplification strategy for specific detection of CirculatingmicroRNAs based on Thioflavin T, Sensors and Actuators B, 2017, 249, 1–7

[3]     Yu Mao, Tingting Fan, Rachel Gysbers, Yin Tan, Feng Liu, Shuo Lin, Yuyang Jiang. A simple and sensitive aptasensor for colorimetric detection of adenosine triphosphate based on unmodified gold nanoparticles, Talanta, 2017,168, 279–285

[4]     Shengnan He, Long Qu, Ying Tan, Feng Liu, Yu Wang, Wei Zhang, Zhiming Cai, Lisha Mou and Yuyang Jiang. A fluorescent aptasensor with product-triggered amplification by exonuclease III digestion for highly sensitive ATP detection, Analytical Methods, 2017, 9, 4837–4842

[5]     Wanxiang Shen, Tao Xiao, Shangying Chen, Feng Liu, Yu Zong Chen, and Yuyang Jiang*. Predicting the Enzymatic Hydrolysis Half-lives of New Chemicals Using Support Vector Regression Models Based on Stepwise Feature Elimination, Molecular Informatics, 2017,36, 1600153

[6]     Haiyang Liu, Yunsheng Dong, Bibo Zhang, Feng Liu, Chunyan Tan, Ying Tan, Yuyang Jiang. An efficient quinoline-based fluorescence sensor for zinc(II) and its application in live-cell imaging, Sensors and Actuators B-Chemical, 2016,234,616-624

[7]     Shengnan He, Long Qu, Zhifa Shen, Ying Tan, Meiyun Zeng, Feng Liu*, Yuyang Jiang*, Yingfu Li, Highly Specific Recognition of Breast Tumors by an RNA-Cleaving Fluorogenic DNAzyme Probe. Analytical Chemistry, 2015,87(1):569-577.

[8]     Bizhu Chu, Feng Liu*, Lu-lu Li, Chao Ding, Kang Chen, Qin-sheng Sun, Zhifa Shen, Ying Tan, Chunyan Tan, Yuyang Jiang*, A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells. Cell Death & Disease, 2015,6, e1686.

[9]     Kang Chen, Bizhu Chu, Feng Liu*, Bin Li, Chun-mei Gao, Lu-lu Li, Qin-sheng Sun, Zhifa Shen, Yuyang Jiang*, New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway. Acta Pharmacological Sinica, 2015,36(9):1074-1084.

[10] Fei Gao, Feng Liu*, Jing Zheng, MeiYun Zeng, Yuyang Jiang*, A Catalytic DNA Probe with Stem-loop Motif for Human T47D Breast Cancer Cells. Analytical Sciences, 2015,31(8):815-822.

[11] Chunmei Gao*, Wei Zhang, Shengnan He, Shangfu Li, Feng Liu*, Yuyang Jiang, Synthesis and antiproliferative activity of 2,7-diamino l0-(3,5-dimethoxy)benzyl-9(10H)-acridone derivatives as potent telomeric G-quadruplex DNA ligands. Bioorganic Chemistry, 2015,60,30-36.

[12] Haiyang Liu, Xiaoshuang Li, Feng Liu, Ying Tan*, Yuyang Jiang. A simple and novel amide ligand based on quinoline derivative used for palladium-catalyzed Suzuki coupling reaction, Journal of Organometallic Chemistry, 2015, 794, 27-32

[13] Zhe Chen, Feng Liu,* Nannan Zhang, Shiying Liu, Yuyang Jiang. p38β, A Novel Regulatory Target of Pokemon in Hepatic Cells, International Journal of Molecular Sciences, 2013,14, 13511-13524

[14] Xiuli Jin, Qinsheng Sun, Feng Liu, Hongwei Yang, Min Liu, Hongxia Liu, Wei Xu, Yuyang Jiang. microRNA 21-mediated suppression of Sprouty1 by Pokemon affects liver cancer cell growth and proliferation, Journal of Cellular Biochemistry,2013,7,1625-1633

[15] Kun Liu, Feng Liu*, Nannan Zhang, Shiying Liu, Yuyang Jiang. Pokemon Silencing Leads to Bim-Mediated Anoikis of Human Hepatoma Cell QGY7703, International Journal of Molecular Sciences, 2012, 13, 5818-5831.

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