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刘红霞 副教授 从事药物学领域研究

 

姓名:刘红霞

职称:副教授,博士生导师

职务: 深圳肿瘤代谢组学重点实验室主任

 

【联系方式】

电话:0755-26036035

E-mail:liuhx@sz.tsinghua.edu.cn

 

【个人简历】

2006.3-至今 清华大学深圳研究生院深圳市(广东省)化学生物学重点实验室-国家重点实验室培育基地,副教授

2005.11-2006.2 香港浸会大学化学系,高级访问学者

2002.9-2005.11 郑州大学化学系化学生物学专业,博士

1987.7-2005.10 郑州大学化学系分析测试中心,副教授

1983.9-1987.7 北京师范大学生物系生物化学专业,理学学士

 

【研究领域】

研究方向为生命分析化学,主要从事液质联用等现代分析技术在生命科学中的基础研究与应用。研究领域涉及分析化学、多肽测序、代谢组学、蛋白质组学研究等。主要参与了科技部973计划、863 专题、国家重大专项,主持国家自然科学基金以及其它国家、省市级科研项目共 11 项。在Chemical Communications, Analytical Chemistry, Journal of Chromatography A等国际著名学术期刊发表SCI科研论文57 篇。

 

【主要荣誉】

2012年深圳市教育系统优秀教师

2007 年获广东省科学技术奖

2007 年深圳市科技创新奖

 

【研究成果】

1. Juyou Lu, Hao Zhang, Xiaowu Chen, Hongxia Liu, Yuyang Jiang, Hua Fu. Palladium-Catalyzed Synthesis of Aromatic Ketones and Isoindolobenzimidazoles via Selective Aromatic CH Bond Acylation. Advanced Synthesis & Catalysis. 2013;355(2-3):529-536.

2. Dan Gao, Hongxia Liu, Jin-Ming Lin, Yini Wang, Yuyang Jiang. Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device. Lab on a Chip. 2013;13(5):978-985.

3. Hao Zhang, Yibao Jin, Hongxia Liu, Yuyang Jiang, Hua Fu. Copper-Catalyzed Cascade Synthesis of 1H-Indolo 1,2-c quinazoline Derivatives. European Journal of Organic Chemistry. 2012;34):6798-6803.

4. Xiaobo Yang, Yue Luo, Yibao Jin, Hongxia Liu, Yuyang Jiang, Hua Fu. Concise and efficient one-pot copper-catalyzed synthesis of H-pyrazolo 5,1-a isoquinolines. Rsc Advances. 2012;2(22):8258-8261.

5. Xiaobo Yang, Shangfu Li, Hongxia Liu, Yuyang Jiang, Hua Fu. Domino reactions of 1-(2-alkoxyaryl)-3-akylprop-2-yn-1-ones with sodium sulfide leading to thiochromen-4-one derivatives. Rsc Advances. 2012;2(16):6549-6554.

6. Xiaobo Yang, Yibao Jin, Hongxia Liu, Yuyang Jiang, Hua Fu. Easy and efficient one-pot synthesis of pyrazolo 1,5-c quinazolines under mild copper-catalyzed conditions. Rsc Advances. 2012;2(29):11061-11066.

7. Liu Li, Liu Hongxia. Study on Optimization Design of a Hoist Roller. Advanced Materials Research. 2012;415-417(460-463.

8. Yibao Jin, Xudong Luan, Hongxia Liu, Chunmei Gao, Shangfu Li, Deliang Cao, Xiaoyan Li, Zongwei Cai, Yuyang Jiang. Pharmacokinetics and metabolite identification of a novel VEGFR-2 and Src dual inhibitor 6-chloro-2-methoxy-N-(2-methoxybenzyl) acridin-9-amine in rats by liquid chromatography tandem mass spectrometry. Talanta. 2012;89(70-76.

9. Feng Jin, Nannan Zhang, Chunyan Tan, Dan Gao, Cunlong Zhang, Feng Liu, Zhe Chen, Chunmei Gao, Hongxia Liu, Shangfu Li, Yuyang Jiang. 2'-Chloro-4'-aminoflavone Derivatives Selectively Targeting Hepatocarcinoma Cells: Convenient Synthetic Process, G2/M Cell Cycle Arrest and Apoptosis Triggers. Archiv Der Pharmazie. 2012;345(7):525-534.

10. Liu Hongxia. Study the Application of PHC Piles to Treat Collapsible Loess Soils. Advanced Materials Research. 2012;446-449(1649-1652.

11. Xiang Gao, Hanzhi Wu, Kim-Chung Lee, Hongxia Liu, Yufen Zhao, Zongwei Cai, Yuyang Jiang. Stable Isotope N-Phosphorylation Labeling for Peptide de Novo Sequencing and Protein Quantification Based on Organic Phosphorus Chemistry. Analytical Chemistry. 2012;84(23):10236-10244.

12. Xiang Gao, Zhi Tang, Minghua Lu, Hongxia Liu, Yuyang Jiang, Yufen Zhao, Zongwei Cai. Suppression of matrix ions by N-phosphorylation labeling using matrix-assisted laser desorption-ionization time-of-flight mass spectrometry. Chemical Communications. 2012;48(82):10198-10200.

13. Dan Gao, Hongxia Liu, Yuyang Jiang, Jin-Ming Lin. Recent developments in microfluidic devices for in vitro cell culture for cell-biology research. Trac-Trends in Analytical Chemistry. 2012;35(150-164.

14. Chunmei Gao, Shangfu Li, Xuliang Lang, Hongxia Liu, Feng Liu, Chunyan Tan, Yuyang Jiang. Synthesis and evaluation of 10-(3,5-dimethoxy)benzyl-9(10H)-acridone derivatives as selective telomeric G-quadruplex DNA ligands. Tetrahedron. 2012;68(38):7920-7925.

15. Lujun Chen, Chao Li, Xin Bi, Hongxia Liu, Renzhong Qiao. Copper-Catalyzed Aerobic Oxidative Synthesis of 5-Substituted Imidazo/Benzimidazoquinazolinones through Intramolecular C-H Amination. Advanced Synthesis & Catalysis. 2012;354(9):1773-1779.

16. Xuyu Zu, Jun Ma, Hongxia Liu, Feng Liu, Chunyan Tan, Lingling Yu, Jue Wang, Zhenhua Xie, Deliang Cao, Yuyang Jiang. Pro-oncogene Pokemon promotes breast cancer progression by upregulating survivin expression. Breast Cancer Research. 2011;13(2).

17. Rui Zhao, Chunyan Tan, Yonghua Xie, Chunmei Gao, Hongxia Liu, Yuyang Jiang. One step synthesis of azo compounds from nitroaromatics and anilines. Tetrahedron Letters. 2011;52(29):3805-3809.

18. Dongmei Zhang, Hongxia Liu, Shusheng Zhang, Xiaolan Chen, Shangfu Li, Cunlong Zhang, Xiangming Hu, Kaishun Bi, Xiaohui Chen, Yuyang Jiang. An effective method for de novo peptide sequencing based on phosphorylation strategy and mass spectrometry. Talanta. 2011;84(3):614-622.

19. Wei Xu, Yibao Jin, Hongxia Liu, Yuyang Jiang, Hua Fu. Copper-Catalyzed Domino Synthesis of Quinazolinones via Ullmann-Type Coupling and Aerobic Oxidative C-H Amidation. Organic Letters. 2011;13(6):1274-1277.

20. Fu Xiujuan, Liu Hongxia. Analysis of Forming Defects and Measures to Prevent Forming Defects of Dn40-type Control Valve. Advanced Materials Research. 2011;160-162(650-655.

21. Xudong Luan, Chunmei Gao, Nannan Zhang, Yuzong Chen, Qinsheng Sun, Chunyan Tan, Hongxia Liu, Yibao Jin, Yuyang Jiang. Exploration of acridine scaffold as a potentially interesting scaffold for discovering novel multi-target VEGFR-2 and Src kinase inhibitors. Bioorganic & Medicinal Chemistry. 2011;19(11):3312-3319.

22. Xudong Luan, Chunmei Gao, Qinsheng Sun, Chunyan Tan, Hongxia Liu, Yibao Jin, Yuyang Jiang. Novel Synthetic Azaacridine Analogues as Topoisomerase 1 Inhibitors. Chemistry Letters. 2011;40(7):728-729.

23. Juyou Lu, Yibao Jin, Hongxia Liu, Yuyang Jiang, Hua Fu. Copper-Catalyzed Aerobic Oxidative Intramolecular Alkene C-H Amination Leading to N-Heterocycles. Organic Letters. 2011;13(14):3694-3697.

24. Yunqi Li, Chunyan Tan, Chunmei Gao, Cunlong Zhang, Xudong Luan, Xiaowu Chen, Hongxia Liu, Yuzong Chen, Yuyang Jiang. Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors. Bioorganic & Medicinal Chemistry. 2011;19(15):4529-4535.

25. Shangfu Li, Hongxia Liu, Yibao Jin, Shuhai Lin, Zongwei Cai, Yuyang Jiang. Metabolomics study of alcohol-induced liver injury and hepatocellular carcinoma xenografts in mice. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 2011;879(24):2369-2375.

26. Xiangming Hu, Chunmei Gao, Chunyan Tan, Cunlong Zhang, Hualin Zhang, Shangfu Li, Hongxia Liu, Yuyang Jiang. Design and Synthesis of N-phosphoryl Peptide Modified Podophyllotoxin Derivatives as Potent Anticancer Agents. Protein and Peptide Letters. 2011;18(12):1258-1264.

 

 

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