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谭春燕 副研究员 主要从事化学生物学领域研究

 

姓名:谭春燕

职称:副研究员/博士生导师

所属学科:化学生物学

 

【联系方式】

电话:0755-26036533

传真:0755-26032094

地址:深圳市南山区西丽镇深圳大学城清华校区J402

Emailtancy@sz.tsinghua.edu.cn

 

【个人简历】

2007/12 至今            清华大学深圳研究生院                                            副研究员

2005/112007/12     清华大学深圳研究生院                                            讲师

2004/9-2005/9            美国西北大学化学系                                                博士后

2000/1-2004/8            美国佛罗里达大学化学系     化学(有机化学)         博士

1995/9-1998/7            厦门大学化学系                     化学(有机化学)         硕士

1991/9-1995/7            厦门大学化学系                     化学                           学士

 

【教学】

化学生物学

 

【研究领域】

谭春燕博士在清华大学深圳研究生院工作以来的研究方向涉及了有机合成、高分子化学、光学表征及生物应用等,主要研究方向包括:

1、基于共轭高分子的荧光分子探针的设计、合成与应用

2、小分子抗肿瘤先导化合物设计、合成与生物活性研究

谭春燕博士主持国家自然科学基金面上项目、教育部留学回国人员科研启动项目和博士点新教师基金项目、深圳市基础研究(杰青项目)和国际合作等多个项目,作为项目副组长参与了国家科技部863、“十一五”新药创制重大专项项目,作为项目主要参与人员参与科技部973、国家自然科学基金重大研究计划项目以及其它多项省部级科研项目的研究。曾获2007 年广东省科技进步奖三等奖1 项和深圳市2007 年科技创新奖1 项。在J. Amer. Chem. Soc., Adv. Mater., Chem. Commun., Langmuir, Tetra. Lett., Bioorg. Med. Chem., ACS Applied Materials & Interfaces等学术期刊上共发表学术论文40余篇,被引用达200余次。

 

【研究成果】

1.    Wu, J.; Tan, Y.; Xie, Y.; Wu, Y.; Zhao, R.; Jiang, Y.; Tan, C., Diazobenzene-containing conjugated polymers as dark quenchers. Chemical Communications 2013, 49, (97), 11379-11381.

2.    Wang, Y.; Wang, R.; Jiang, Y.; Tan, C.; Fu, H., Copper-catalyzed domino synthesis of 4-oxopyrimido [1,2-a] indole derivatives. Advanced Synthesis & Catalysis 2013, 335, (14-15), 2928-2938.

3.    Liu, R.; Tan, Y.; Zhang, C.; Wu, J.; Mei, L.; Jiang, Y.; Tan, C., A real-time fluorescence turn-on assay for trypsin based on a conjugated polyelectrolyte. Journal of Materials Chemistry B 2013, 1, (10), 1402-1405.

4.    Jin, F.; Gao, D.; Zhang, C.; Liu, F.; Chu, B.; Chen, Y.; Chen, Y. Z.; Tan, C.; Jiang, Y., Exploration of 1-(3-chloro-4-(4-oxo-4H-chromen-2-yl)phenyl)-3-phenylurea Derivatives as Selective Dual Inhibitors of Raf1 and JNK1 Kinases for Anti-tumor Treatment. Bioorg. Med. Chem. 2013, 21, 824-831.

5.    Jin, F.; Gao, D.; Wu, Q.; Liu, F.; Chen, Y.; Tan, C.; Jiang, Y., Exploration of N-(2-aminoethyl)piperidine-4-carboxamide as a potential scaffold for development of VEGFR-2, ERK-2 and Abl-1 multikinase inhibitor. Bioorg. Med. Chem. 2013, 21, (18), 5694-5706.

6.    Zhang, C.; Tan, C.; Ding, H.; Xin, T.; Jiang, Y., Selective VEGFR Inhibitors for Anticancer Therapeutics in Clinical Use and Clinical Trials. Current Pharmaceutical Design 2012, 18, (20), 2921-35.

7.    Xie, Y.; Zhao, R.; Tan, Y.; Zhang, X.; Liu, F.; Jiang, Y.; Tan, C., Conjugated Polymer-Based Real-Time Fluorescence Caspase Assays. ACS Applied Materials & Interfaces 2012, 4, (1), 405-410.

8.    Xie, Y.; Tan, Y.; Liu, R.; Zhao, R.; Tan, C.; Jiang, Y., Continuous and Sensitive Acid Phosphatase Assay Based on a Conjugated Polyelectrolyte. ACS Applied Materials & Interfaces 2012, 4, 3784-3787.

9.    Tan, Y.; Zhang, X.; Xie, Y.; Zhao, R.; Tan, C.; Jiang, Y., Label-free fluorescent assays based on aptamer-target recognition. Analyst 2012.

10.   Zhu, F.; Qin, C.; Tao, L.; Liu, X.; Shi, Z.; Ma, X. H.; Jia, J.; Tan, Y.; Cui, C.; Lin, J. S.; Tan, C. Y.; Jiang, Y. Y.; Chen, Y. Z., Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, (31), 12943-12948.

11.   Zhang, C.; Tan, C.; Zu, X.; Zhai, X.; Liu, F.; Chu, B.; Ma, X.; Chen, Y.; Gong, P.; Jiang, Y., Exploration of (S)-3-aminopyrrolidine as a potentially interesting scaffold for discovery of novel Abl and PI3K dual inhibitors. Eur. J. Med. Chem. 2011, 46, (4), 1404-1414.

12.   Li, Y. Q.; Tan, C. Y.; Gao, C. M.; Zhang, C. L.; Luan, X. D.; Chen, X. W.; Liu, H. X.; Chen, Y. Z.; Jiang, Y. Y., Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors. Bioorg. Med. Chem. 2011, 19, (15), 4529-4535.

13.   Tan, C.; Xie, Y.; He, X.; Wang, K.; Jiang, Y., Hyper-Efficient Quenching of a Conjugated Polyelectrolyte by Dye-Doped Silica Nanoparticles: Better Quenching in the Nonaggregated State. Langmuir 2010, 26, (3), 1528-1532.

14.   Zhang, N.; Tan, C. Y.; Cai, P. Q.; Zhang, P. Z.; Zhao, Y. F.; Jiang, Y. Y., RNA interference in mammalian cells by siRNAs modified with morpholino nucleoside analogues. Bioorg. Med. Chem. 2009, 17, (6), 2441-2446.

15.   Zhang, N.; Tan, C.; Cai, P.; Zhang, P.; Zhao, Y.; Jiang, Y., The design, synthesis and evaluation of hypoxia-activated pro-oligonucleotides. Chemical Communications 2009, (22), 3216-3218.

 

【学术兼职】

ACS Applied Materials & Interfaces编委

Protein & Peptide Letters编委

 

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