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吴耀炯 教授 主要从事干细胞组织再生医学研究

 

 姓名:吴耀炯

职称:教授,博士生导师

所属学科:生物学

 

【联系方式】

电话/传真:26036348

E-mailwu.yaojiong@sz.tsinghua.edu.cn

 

【个人简历】

1978-1983 青岛医学院,医学学士

1983-1986 兰州大学医学院,硕士 (病理)

1999-2003 多伦多大学,理学博士 (实验医学与病理生物)

1986-1997首都医科大学附属医院,历任住院医师、主治医师、副主任医师、副教授、学科带头人。

1997-1999 加拿大英属哥伦比亚大学博士后

2003-2005 美国哈佛医学院、杜克大学博士后(干细胞组织再生医学)

2005-2008 加拿大阿尔伯特大学助理教授

2008- 清华大学深圳研究生院教授

 

【教学】

开设课程:干细胞转化医学(英文),干细胞再生医学前沿

讲授课程:分子细胞生物学进展,基因分子生物学

 

【研究领域】

近10多年主要从事干细胞再生医学研究,涉及间充质干细胞、皮肤干细胞和神经干细胞,主要研究提高干细胞组织再生修复效果的方法及分子机制,在增进间充质干细胞移植后向损伤组织迁徙的能力、改进干细胞皮肤再生微环境及干细胞对毛囊等皮肤附属器官的再生等研究领域取得了一定的研究成果,在Circulation Research、Stem Cells、Nature Protocols、Nature Communications等杂志发表SCI收录论文50篇,论文他引3000余次。申请美国专利3项。主持国家自然基金重点、国家863干细胞专项、广东省自然基金重点等项目。

 

【研究成果】

代表性论文:

[1] Wang X, Chen H, Tian R et al. Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF. Nature Communication. 2017; accepted.

[2] Zhou Y, Chen H, Li H and Wu Y. 3D culture increases pluripotent gene expression in mesenchymal stem cells through relaxation of cytoskeleton tension. J Cell Mol Med. 2017; [Epub ahead of print]

[3] Wang X, Wang X, Cai T et al. De novo hair follicle and sebaceous gland regeneration with cultured stem cells. Stem Cells Translational Medicine. 2016; 5(12):1695-1706.

[4] Wang X, Wang J, Guo L et al. Self-assembling peptide hydrogel scaffolds support stem cell-based hair follicle regeneration. Nanomedicine. 2016; 12(7):2115-2125

[5] Wang S, Guo L, Ge J et al. Excess Integrins Cause Lung Entrapment of Mesenchymal Stem Cells. Stem Cells. 2015;33:3315-3326.

[6] Guo L, Zhou Y, Wang S et al. Epigenetic changes of mesenchymal stem cells in three-dimensional (3D) spheroids. Journal of Cellular and Molecular Medicine. 2014;18:2009-2019.

[7] Guo L, Ge J, Zhou Y et al. Three-dimensional spheroid-cultured mesenchymal stem cells devoid of embolism attenuate brain stroke injury after intra-arterial injection. Stem Cells and Development. 2014;23:978-989.

[8] Wang X, Ge J, Tredget EE et al. The mouse excisional wound splinting model, including applications for stem cell transplantation. Nat Protoc. 2013;8:302-309.

[9] Li Z, Liu C, Xie Z et al. Epigenetic dysregulation in mesenchymal stem cell aging and spontaneous differentiation. PloS One. 2011;6:e20526.

[10] Wu Y, Zhao RC, Tredget EE. Concise review: bone marrow-derived stem/progenitor cells in cutaneous repair and regeneration. Stem Cells. 2010;28:905-915.

[11] Chen L, Tredget EE, Wu PY et al. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PloS One. 2008;3:e1886.

[12] Wu Y, Chen L, Scott PG et al. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells. 2007;25:2648-2659.

[13] Wu Y, Ip JE, Huang J et al. Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. Circulation Research. 2006;99:315-322.

[14] Wu Y, Chen L, Zheng PS et al. beta 1-Integrin-mediated glioma cell adhesion and free radical-induced apoptosis are regulated by binding to a C-terminal domain of PG-M/versican. The Journal of Biological Chemistry. 2002;277:12294-12301.

代表性论著:

[1] Wu Y and Zhao RC. Mesenchymal Stem Cell Homing to Injured Tissues. Essentials of Mesenchymal Stem Cell Biology and Its Clinical Translation (edited by Zhao, RC). Springer Dordrecht Heidelberg New York London, 2013.

[2] Wu Y and Tredget EE. Pathology of Tissue Regeneration and Repair: Skin Regeneration. Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms (edited by Frank PG), Elsevier, 2013.

 

【奖励荣誉】

获加拿大CIHR Fellowship Award

 

 

 

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