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何永红 研究员 主要从事医学光学技术应用等领域研究

 

姓名:何永红

职称:研究员(博士生导师)

职务:生命与健康学部主任、光学检测与成像实验室主任

所属学科:生物医学工程、光学

【联系方式】

清华大学深圳研究生院光学检测与成像实验室

广东省深圳市南山区西丽大学城清华校区D302A

邮编PC: 518055

TEL: +86-755-26036873

FAX: +86-755-26036395

Email: heyh@sz.tsinghua.edu.cn

【个人简历】

2004-今,清华大学深圳研究生院光学检测与成像实验室,先后任讲师、副教授、教授(2009)、博导、主任

20022004英国Cranfield大学生命科学技术研究所博士后、Research Fellow

19962002,华南师范大学激光生命科学研究所(国家重点学科),攻读并获光学硕士、博士学位

19891994就读于安徽医科大学,获医学学士学位

【教学】

生物医学光学, 医用光学仪器

【研究领域】

多年从事生物医学光学方法、技术、应用及仪器的交叉学科科研工作,主持国家自然科学基金(8项)、国家863计划、省市科技计划、香港合作、企业科技开发等多项目,创建了初具规模的生医光学检测与成像实验室基地。先后开展光学相干层析(OCT)技术、光学弱测量传感技术、表面等离体共振SPR及其非标记生物分子相互作用传感应用、高通量生物芯片分析技术等研究工作:

在光学成像领域,实现OCT技术仪器攻关并产业化,参与制定国家标准两项;在方法学上,提出并实现了差分吸收OCT技术测量眼房水中糖浓度(Journal of Biomedical Optics),获授权系列专利。针对血流检测多普勒OCT对入射角度的依赖,提现并实现基于相关和OCT测量流体速度分布的新方法,消除入射角影响(Laser Physics Letters)。

在生物分子传感领域,围绕提高灵敏度和提高检测通量两个主题研究光学检测方法、技术与应用,开拓了基于光学弱测量技术的分子传感器,实现了基于偏振干涉的频域弱测量系统,得到了基于弱值放大的稳定测量,首次将弱测量系统用于生物分子传感器,在普通玻璃片上实现了高分辨的蛋白分子检测(Optics Letters, Biosensors and Bioelectronics)。在非标记SPR生物传感器中,分别开拓了对称波导结构的长程SPR分析技术、偏振干涉调制SPR传感技术和线扫描SPR光谱成像技术,将折射率分辨率提高到2x10-8RIU。(Analytical ChemistryBiosensors and Bioelectronics

在高通量荧光生物芯片领域,我们提出了数字化编码的液相生物芯片概念,利用物理中激光诱导的原子光谱对微球进行数字编码,与现有靠荧光强度这一模拟量编码的技术相比,编码准确性、稳定性得以质变的提高,同时去除了噪声提高了检测信噪比,这一技术的实用性也因此大幅提高(Scientific Reports,Analytical Chemistry)。

【研究成果】

发表SCI论文100多篇;授权中国专利20多项;所研发的技术被制定成国家标准2项。近5年主要论文有:

[1]      Zhiyuan Shen, Xiaorui Guo, Yilong Zhang, Dongmei Li, Yonghong He*, Imaging performance enhancement of short coherence digital holographic microscopy by tissue optical clearing, Biomedical Optics Express, 8(4): 2036-2054, 2017

[2]  Dongmei Li, Tian Guan, Yonghong He*, Qinghua He, Yilong Zhang, Xiangnan Wang, Zhiyuan Shen, Yuxuan Yang, Zhen Qiao Yanhong Ji*, A differential weak measurement system based on Sagnac interferometer for self-referencing biomolecule detection, Journal of Physics D:Appl. Phys. 50 (2017) 49LT01 2017.  https://doi.org/10.1088/1361-6463/aa92a3

[3]      Dongmei Li, Qinghua He, Yonghong He*, Meiguo Xin*, Yilong Zhang, Zhiyuan Shen, Molecular imprinting sensor based on quantum weak measurement, Biosensors and Bioelectronics, DOI: http://dx.doi.org/10.1016/j.bios.2017.03.021, 2017

[4]      Liang Zhu, Guohua Li, Yonghong He*, Hui Tan* and Shuqing Sun*, Scattering measurement of single particle for highly sensitive homogeneous detection of DNA in serum, Talanta, 178:545-551, 2017.

[5] Qinghua He, Dongmei Li, Yonghong He*, et al. Optical demodulation system for digitally encoded suspension array in fluoroimmunoassay. Journal of Biomedical Optics, 22(9): 1-7, 2017

[6]  Qinghua He, Dongmei Li, Yonghong He*, Yilong Zhang, Xuejing Chen, Siyu Liu, Microbeads preparation with reversed-phase microemulsion and ultraviolet light curing for digital encoding suspension array, RSC Advances, 7: 32727 - 32730, 2017

[7]  Liang Zhu, Guohua Li, Yonghong He*, Hui Tan* and Shuqing Sun*, Digital immunoassay of prostate specific antigen using gold nanorods and magnetic nanoparticles, RSC Advances, 7:27595 - 27602, 2017

[8]  Guohua Li, Liang Zhu, Yonghong He*, Hui Tan* and Shuqing Sun*, Digital triplex DNA assay based on color-encoded plasmonic nanocrystals, Anal Bioanal Chem, DOI: 10.1007/s00216-017-0307-9, 2017

[9] Dongmei Li, Tian Guan, Jingying Jiang, Yonghong He*, A non-disturbing transverse acoustic sensor based on weak measurement in Mach-Zehnder interferometer, Optical Engineering, 56(3), 034107 (2017). doi: 10.1117/1.OE.56.3.034107.

[10]  Yixi Liu, Le Liu, Yonghong He*, Qinghua, He, Hui Ma,Quantum-dots-encoded-microbeads based molecularly imprinted Polymer Biosensors and Bioelectronics, Biosensors and Bioelectronics, 77: 886–893, 2016

[11]  Guohua Li, Liang Zhu, Zhenjie Wu, Yonghong He*, Hui Tan* and Shuqing Sun*, Digital Concentration Readout of DNA by Absolute Quantification of Optically Countable Gold Nanorods,Analytical Chemistry, 88 (22):10994–11000, 2016

[12]  Yilong Zhang, Dongmei Li, Yonghong He*, Zhiyuan Shen, Qinghua He, Optical weak measurement system with common path implement for label-free biomolecules sensing, Optics Letters, 41(22):5409-5412, 2016.

[13]  Qinghua He, Yixi Liu, Yonghong He*, Liang Zhu, Yilong Zhang and Zhiyuan Shen, Digital multiplexing of suspension array using laser induced breakdown spectroscopy, Scientific Reports, 6, 36511; doi: 10.1038/srep36511, 2016.

[14]  Yixi Liu, Le Liu, Yonghong He*, Liang Zhu, and Hui Ma,Decoding of Quantum Dots Encoded Microbeads Using a Hyperspectral Fluorescence Imaging Method, Analytical Chemistry, 87 (10): 5286–5293, 2015

[15]  Yixi Liu, Yong Wang, Le Liu, Yonghong He*, Qinghua He, Yanhong Ji, The detection method for small molecules coupled with a molecularly imprinted polymer/quantum dot chip using a home-built optical system, Anal Bioanal Chem, DOI 10.1007/s00216-016-9620-y, 2016

[16]  Zhenling Chen, Le Liu, Yonghong He*, et al. Resolution Enhancement of Surface Plasmon Resonance Sensors with Spectral Interrogation: Resonant Wavelength Considerations, Applied Optics, 55(4): 884-891, 2016

[17]  Dongmei Li, Zhiyuan Shen, Yonghong He*, Yilong Zhang, Zhenling Chen, Hui Ma, Application of quantum weak measurement for glucose concentration detection, Applied Optics, 55(7): 1697-1702, 2016

[18]  Pengfei Zhang, Le Liu, Yonghong He*, Temperature regulated surface plasmon resonance imaging system for bioaffinity sensing, Plasmonics, 11: 771-779, 2016.

[19]  Yilong Zhang, Le Liu, Yi Tao, Yonghong He* Pengfei Zhang, Zhonghua Cai, A fiber-based fluorometric system for algal classification in situ, Optics & Laser Technology, 76:121-126, 2016

[20]  Pengfei Zhang, Le Liu, Yonghong He* et al. Self-Referenced Plasmon Waveguide Resonance Sensor Using Different Waveguide Modes. Journal of Sensors, 2015: 945908.

[21]  Pengfei Zhang, Le Liu, Yonghong He*, Zihao Xu, Yanhong Ji, Hui Ma, One-dimensional angular surface plasmon resonance imaging based array thermometer, Sensors & Actuators: B., 207: 254–261( 2015).

[22]  Le Liu, Jun Guo, Yonghong He*, Pengfei Zhang, Yilong Zhang, and Jihua Guo, Study on the despeckle methods in angular surface plasmon resonance imaging sensors, Plasmonics, 3,10729-737, 2015

[23]  Pengfei Zhang, Le Liu, Yonghong He *, Yanfei Zhou, Yanhong Ji, Hui Ma, Noninvasive and Real-Time Plasmon Waveguide Resonance Thermometry, Sensors, 15: 8481 -8498, 2015.

[24]  Ang Li, Zhouyi Guo, Qing Peng, Chan Du, Xida Han, Le Liu, Jun Guo, Yonghong He, and Yanhong Ji, A saccharides sensor developed by symmetrical optical waveguide-based surface plasmon resonance, Journal of Innovative Optical Health Sciences,8(2): 1550003,(2015)

[25]  Yanfei Zhou, Pengfei Zhang, Yonghong He*, Zihao Xu, Le Liu, Yanhong Ji, Hui Ma, Plasmon waveguide resonance sensor using an Au–MgF2 structure, Applied Optics, 53(28) : 6344-6350, 2014.

[26]  Pengfei Zhang, Le Liu, Yonghong He*, Zhiyuan Shen, Jun Guo, Yanhong Ji, Hui Ma, Non-scan and real-time multichannel angular surface plasmon resonance imaging method, Applied Optics, 53 (26): 6037-6042, 2014.

[27]  Chuan Liu, Heng Shi, Yonghong He*, Multi-channel, line-monitoring sensing approach based on long-range surface plasmons, Plasmonics, 9(3): 513-518,2014.

[28]  Pengfei Zhang, Le Liu, Yi Tao, Qiang Huang, Heng Shi, Chan Du, Xihui Zhang, Yonghong He, An amplitude modulation fluorometric method for phytoplankton classified measure, Optik, 125: 2661-2664, 2014.

[29]  Chan Du, Le Liu, Jun Guo, Yonghong He*, Jihua Guo, Shuqing Sun, Hui Ma, A biosensor using coupled plasmon waveguide resonance combined with hyperspectral fluorescence analysis, Journal of Innovative Optical Health Sciences, 7(1):1450017-1(2014).

[30]  Zhiyi Liu, Qing Peng, Heng Shi, Shuqing Sun, Jun Guo, Le Liu, Yanhong Ji, Jihua Guo, Hui Ma, Yonghong He*, A MgF2-Au-MgF2-Polydopamine Biosensing System, Analytical Methods, DOI: 10.1039/C3AY41380B, (2013).

[31]  Chan Du, Le Liu, Lin Zhang, Jun Guo, Jihua Guo, Hui Ma and Yonghong He* , Multi-Channel Hyperspectral Fluorescence Detection Excited by Coupled Plasmon-Waveguide Resonance, Sensors, 13(10), 13892-13902; doi:10.3390/s131013892, (2013)

[32]  Heng Shi, Zhiyi Liu, Xiaoxiao Wang, Jun Guo, Le Liu, Lin Luo, Jihua Guo, Hui Ma, Shuqing Sun, Yonghong He*, A symmetrical optical waveguide based surface plasmon resonance biosensing system, Sensors & Actuators: B. Chemical, 185:91– 96 (2013)

[33]  Xinyuan Chong, Le Liu, Zhiyi Liu, Suihua Ma, Jun Guo, Yanhong Ji and Yonghong He*, Detect the hybridization of single-stranded DNA by parallel scan spectral surface plasmon resonance imaging, Plasmonics, DOI 10.1007/s11468-013-9530-1, 2013.

[34]  Le Liu, Xiangliang Chen, Zhiyi Liu, Suihua Ma, Chan Du, Yonghong He*, Polarization Interference Interrogation of Angular Surface Plasmon Resonance Sensors with Wide Metal Film Thickness Tolerance, Sensors & Actuators: B. Chemical, 173: 218–224, ( 2012)

[35]  Zhiyi Liu, Le Liu, Xiaoxiao Wang, Heng Shi, Xinyuan Chong, Suihua Ma, Yanhong Ji, Jihua Guo, Hui Ma, Yonghong He*, Polarization Interferometry Based Wavelength-Interrogation Surface Plasmon Resonance Imager for Analysis of Microarrays, Journal of Biomedical Optics, 17: 036002 (2012)

[36]  Sunan Deng, Le Liu, Zhiyi Liu, Zhiyuan Shen, Guohua Li, Yonghong He*, Line-scanning Raman Imaging Spectroscopy for Detection of Fingerprints, Applied Optics, 51: 3701-3706, ( 2012).

【学术兼职】

深圳市生物医学工程学会,理事

【奖励荣誉】

获广东省科学技术一、三等奖,广东省省级南粤优秀教师奖、清华大学校级优秀工作者,教育部新世纪优秀人才获得者。

版权所有@清华大学深圳研究生院 地址:深圳大学城清华园区 邮编:518055 Email:info@sz.tsinghua.edu.cn